Summary of Multiple Determinations of Arterial Blood pH , Pco 2 , and Serum Electrolyte Concentrations during Control Periods and during Metabolic Alkalosis Induced

Dr. Cannon holds a Career Development Award No. HE-15031. Dr. Heinemann is a Career Scientist, Health Research Council of the City of New York (I-189). Address requests for reprints to Dr. Roberta M. Goldring, New York University School of Medicine, 550 First Avenue, New York 10016. Received for publication 20 January 1967 and in revised form 7 September 1967. when renal hydrogen ion excretion was increased (ethacrynic acid). Alveolar hypoventilation did not occur when induction of similar degrees of extracellular alkalosis was accompanied by marked potassium loss and no demonstrable increase in external hydrogen loss (thiazides and aldosterone) . These observations suggest that respiratory depression does not necessarily accomp)any extracellular alkalosis but depends on the effect of the mode of induction of the alkalosis on the tissues involved in the control of ventilatioii.